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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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VIDEO

What is Viagra (sildenafil)?

Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.

under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.

Buy Viagra Online : Know the Dosage

The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.

Side Effects

MedicationOnsetDuration
Sildenafil (Viagra)30-60 minutes4-5 hours

The most common side effects consist of the following:

  • Headache, nausea, and dizziness
  • Stuffy nose, nosebleed
  • Temporary redness of neck and face
  • Backache, indigestion

If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:

  • Severe dizziness
  • Nausea
  • Chest/jaw/left arm pain
  • Fainting

Some patients may experience serious side effects; if you experience these, get medical help right away. Serious side effects include:

  • Temporary memory loss
  • Seizures
  • Serious allergic reaction, including rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.

We offer more than just lower prices on

sildenafil in Canada and free shipping. Some patients experience side effects that are not listed. If you have any concerns regarding Viagra, contact your physician.

Take note: This medicine is available only with a valid doctor's prescription.Side effects include:

Contact your doctor right away if you have any concerns about Viagra and have them available for free.

refroying Viagra

If you experience side effects, you may want to consider taking Viagra to restore your daily flow of medication to your system. If you experience side effects, you may want to stop and get medical help as they could be life-threatening.

Do not take Viagra if you:
  • Are allergic to sildenafil or any other PDE5 inhibitors such as Avanafil, or any other medications containing sildenafil.
  • Take any hospital or emergency medicine treatment such as Acetaminophen, or Couple that contains nitrates (e.g., isosorbide, isosorbide) for patients with angina or heart failure.
  • Take riociguat (or other related medication) daily for a certain amount of time. It is not advisable to take this medication for more than 3 days while you are taking irretrievable pulmonary hypertension or for 12 hours after you began be displayed for severe sunburn.
  • Have a history of heart failure or heart attack
  • Are prescribed or receiving other related medication such as metoprolol, riociguat, or a proton pump inhibitor (e.g.

Viagra Connect is available in Ireland for erectile dysfunction treatment which does not require a prescription. The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online or over the counter in your pharmacy, without a trip to your doctor.

We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.

You can select your convenient store to collect your product and fill in the online form required.APharmacist will contact you to let you know your product is ready for collection, or you can buy onlineand complete the questions included.

When purchased online, a pharmacist will contact you by phone if they have any further questions and to advise you on the safe use of this medicine. If they are unable to speak to you when required your order may be delayed or the pharmacy medicine part of your order cancelled.

Please ensure your contact details are correct before ordering this medicine.Suitable for

Viagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex

Age RestrictionYou must be at least 18 years old to purchase this product.

Directions for use:

Please read the enclosed leaflet carefully before use.

• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.

Hazards and Cautions

Do NOT take if you:

  • do not have an erection problem
  • take any nitrate medicine for chest pain or heart failure
  • take riociguat (or other guanylate cyclase stimulators) for high blood pressure in the lungs
  • take ritonavir for the treatment of HIV
  • have been advised by your doctor to avoid sexual activity because of a problem with your heart or blood vessels
  • have a severe heart or liver problem
  • have low blood pressure
  • have ever had severe vision loss or a rare inherited eye disease
  • have a deformed penis
  • have an allergy to any of the ingredients in this product

Talk to your pharmacist or doctor before taking if you:

  • get very breathless or feel chest pain with light or moderate physical activities
  • have a heart problem
  • have high blood pressure that is not controlled
  • take any other medicines listed in the package leaflet
  • take any other treatment for erectile dysfunction
  • ever had a persistent erection that lasted for more than 4 hours
  • have a stomach ulcer or bleeding disorder
  • have diagnosed mild to moderate liver problems
  • have diagnosed severe kidney problems
This is a TASKaves service.

You must talk to a doctor before you takeViagra Connector any other Viagraivalent medication.

Abstract

Background: Sildenafil (Viagra®) is an oral drug that is used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). The pharmacological action of sildenafil is mediated by the inhibition of phosphodiesterase type 5 (PDE5), an enzyme that produces cGMP (cyclic guanosine monophosphate), an inhibitor of cyclic guanosine monophosphate (cGMP). This article reviews the pharmacological properties of sildenafil and reviews how PDE5 was inhibited in patients with PAH.

Methods: A retrospective analysis was conducted of patients with PAH treated with sildenafil and those with erectile dysfunction (ED) in the United Kingdom. Patients were classified as responders (ED, ED >24) if the ED was not present on a daily basis. Sildenafil was used as a reference group for statistical analysis. Patients were further classified as non-responders (NRE) if the ED was not present on a daily basis. The primary outcome was the rate of erectile dysfunction (ED) as measured by a global assessment of erectile function (GFR).

Results: The average number of patients receiving sildenafil at baseline was 3.4, of whom 9 were responders. The mean duration of treatment with sildenafil was 4.1 months, with a median of 4.8 months (95% confidence interval [CI]: 3.3-5.0). The rate of ED as measured by the global assessment of erectile function (GFR) did not change significantly from baseline (6.3 vs 3.4, P=0.26).

Conclusion: Sildenafil is an effective drug treatment for ED in patients with PAH.

Keywords

Pharmacological properties of sildenafil

  • Phosphodiesterase type 5 inhibitor
  • Sildenafil
  • Effects of sildenafil on the function of the erectile tissue in the rat (RHT)
  • Effects of sildenafil on phosphodiesterase type 5 (PDE5) inhibition
  • Effects of sildenafil on PDE5 inhibition in the rat
  • Effects of sildenafil on the function of the erectile tissue in the rat

Introduction

Sildenafil (Viagra®) is a prescription-only drug that is used to treat erectile dysfunction (ED). The pharmacological action of sildenafil is mediated by inhibiting phosphodiesterase type 5 (PDE5), a enzyme that produces cGMP (cyclic guanosine monophosphate). This mechanism of action is different from that of the other phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil (Viagra®) and avanafil (Stendra®).

Sildenafil (Viagra®) has been approved by the US Food and Drug Administration (FDA) for the treatment of ED in patients with PAH. Sildenafil is approved for use in patients with erectile dysfunction. However, the safety and efficacy of sildenafil in patients with ED are not fully understood. Therefore, the aim of this study was to examine the safety and efficacy of sildenafil treatment in patients with PAH.

A retrospective analysis was conducted from January 2018 to December 2021, at the National Hospital Organization of India (NHOI) Department of Health. The study protocol was approved by the institutional review board (IRB) of NHOI (IRB No. 2018/078/MHC-NUH-ODM-2018-0006).

Figure 1The flow diagram of study.

A retrospective study was performed from January 2018 to December 2021, at the National Hospital Organization of India (NHOI) Department of Health.

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